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Catalog of preclinical models

With over 80 preclinical models (in vivo/in vitro), OPALE offers a wide variety of models adapted for the preclinical studies required in the development of treatments for leukemia and related diseases. These models from the OPALE catalog are available for partnership research  in strict compliance with the current regulatory and legal framework concerning ethical imperatives, intellectual property protection, and legal requirements.

Category Entity Models Pathology Specification Sample type Number of models Genetics characterization
In vitro EMiLy (INSERM U1160) Organoids MSD/AML 3D Model (Artificial BM organoid) NK cells/MSC/blastes - - -
In vitro CRCM / IPC (UMR-1068) PDX B-ALL - Diagnosis 4 All
In vitro CRCM / IPC (UMR-1068) PDX B-ALL - Relapse 4 All
In vitro CRCM / IPC (UMR-1068) PDX AML - Diagnosis 10 All
In vitro CRCM / IPC (UMR-1068) PDX B-ALL - - 9 All
In vitro CRCM / IPC (UMR-1068) PDX AML - Relapse 14 All
In vitro CRCM / IPC (UMR-1068) PDX AML - - 8 All
In vitro CRCM / IPC (UMR-1068) CDX T-ALL - - 3 -
In vitro CRCM / IPC (UMR-1068) CDX AML - - 10 -
In vitro CRCM / IPC (UMR-1068) CDX APDCL - - 2 -
In vitro C3M (UMR-1065) Human primary cells AML - Diagnosis - -
In vitro C3M (UMR-1065) Human primary cells AML - Relapse - -
In vitro CRCT (UMR-1037) Human primary cells B-ALL - Diagnosis - -
In vitro CRCT (UMR-1037) Human primary cells B-ALL - Relapse - -
In vitro UMR - 1274 Human primary cells T-ALL - Diagnosis - -
In vitro UMR - 1274 Human primary cells T-ALL - Relapse - -
In vitro IDMIT (UMR-1184) Human primary cells AML Mononuclear myeloid cells (MMC) Diagnosis - -
In vitro IDMIT (UMR-1184) Human primary cells AML Mononuclear myeloid cells (MMC) Diagnosis - -
In vitro U1069-N2COx Human primary cells AML - Diagnosis - -
In vitro U1069-N2COx Human primary cells AML - Relapse - -
In vitro Cochin Institute (UMR-1016) Human primary cells AML - Diagnosis - -
In vitro Cochin Institute (UMR-1016) Human primary cells AML - Relapse - -
In vitro U1312 BRIC Human primary cells AML - Diagnosis - -
In vitro U1312 BRIC Human primary cells AML - Relapse - -
In vitro CRSA (UMR-938) Human primary cells DNMT3A AML - Diagnosis - All
In vitro CRSA (UMR-938) Human primary cells DNMT3A AML - Relapse - All
In vitro CRSA (UMR-938) Human primary cells TET2 AML - Diagnosis - All
In vitro CRSA (UMR-938) Human primary cells TET2 AML - Relapse - All
In vitro CRSA (UMR-938) Human primary cells TP53 AML - Diagnosis - All
In vitro CRSA (UMR-938) Human primary cells TP53 AML - Relapse - All
In vitro IDMIT (UMR-1184) Human primary cells CML CD34+ cells Diagnosis - -
In vitro C3M (UMR-1065) Human primary cells CMML - Diagnosis - -
In vitro C3M (UMR-1065) Human primary cells CMML - Relapse - -
In vitro U1069-N2COx Human primary cells Normal bone marrow - - - -
In vitro CRSA (UMR-938) Human primary cells Shwachman Diamond - Follow-up - -
In vitro Cochin Institute (UMR-1016) Human primary cells MDS - Diagnosis - -
In vitro Cochin Institute (UMR-1016) Human primary cells MDS - Evolution - -
In vitro C3M (UMR-1065) Human primary cells MDS - Diagnosis - -
In vitro C3M (UMR-1065) Human primary cells MDS - Relapse - -
In vitro INSERM UMR-S 1131 (UMR-1131) Human primary cells ET, PV, MF - Diagnosis - All
In vitro INSERM UMR-S 1131 (UMR-1131) Human primary cells ET, PV, MF - Follow-up - All
In vitro CRSA (UMR-938) Transduced human primary cells DNMT3A Clonal Hematopoiesis - - - All
In vitro CRSA (UMR-938) Transduced human primary cells TET2 Clonal Hematopoiesis - - - All
In vitro CRSA (UMR-938) Transduced human primary cells TP53 Clonal Hematopoiesis - - - All
In vitro UMR - 1274 Mouse tumor-derived cell line T-ALL ICN1 - - -
In vitro UMR - 1274 Mouse tumor-derived cell line T-ALL TAL1/LMO1 - - -
In vivo CRCM / IPC (UMR-1068) CDX T-ALL - - 3 -
In vivo CRCM / IPC (UMR-1068) CDX AML - - 10 -
In vivo CRCM / IPC (UMR-1068) CDX APDCL - - 2 -
In vitro CRCM / IPC (UMR-1068) Mouse tumor-derived cell line AML FLB1 - - -
In vitro CRCM / IPC (UMR-1068) Mouse tumor-derived cell line AML C1498 - - -
In vivo IDMIT (UMR-1184) Mouse model Myelofibrosis C57BL/6 (B6.129(Cg)-Leprtm2(cre)Rck/J (008320) _ B6.129-Ppargtm2Rev/J (004584)) - - -
In vivo CRCT (UMR-1037) Mouse model B-ALL B-ALL Pax5-ELN - - -
In vivo CRCT (UMR-1037) Mouse model B-ALL B-ALL PAX5-P80R - - -
In vivo CRCT (UMR-1037) Mouse model AML KI Gata2µ/R396Q - - -
In vivo Cochin Institute (UMR-1016) Mouse model AML MLL-AF9 - - -
In vivo Cochin Institute (UMR-1016) Mouse model AML MLL-ENL - - -
In vivo CRCM / IPC (UMR-1068) Mouse model AML iMLL-AF9 x Jam3 cKO - - -
In vivo CRCM / IPC (UMR-1068) Mouse model AML cMLL-AF9 - - -
In vivo U1312 BRIC Mouse model AML AML Meis/HoxA9 - - -
In vivo U1312 BRIC Mouse model AML AML/AF9 - - -
In vivo IDMIT (UMR-1184) Mouse model CML LMC-BCR-ABL - - -
In vivo GenCellDis (UMR-944) Mouse model Fanconi anemia FANCG-/- - - -
In vivo EMiLy (INSERM U1160) Mouse model Waldenström's macroglobulinemia Cxcr4+/1013 x Myd88B-L252P =Waldenstrom-like disease - - -
In vivo IDMIT (UMR-1184) Mouse model Myelofibrosis Myelofibrosis TPOhigh - - -
In vivo C3M (UMR-1065) Mouse model MSD/AML LAMP2-Vav-Cre - - -
In vivo C3M (UMR-1065) Mouse model MSD/AML LAMP2-CEBPa - - -
In vivo EMiLy (INSERM U1160) Mouse model Richter's Syndrome Cxcr4+/1013xEµ-TCL1=CLL/Richter syndrome like disease - - -
In vivo U1069-N2COx Mouse model AML FLA2, FLB1 - - -
In vivo CRCM / IPC (UMR-1068) PDX B-ALL - Diagnosis 4 All
In vivo CRCM / IPC (UMR-1068) PDX B-ALL - Relapse 4 All
In vivo CRCT (UMR-1037) PDX B-ALL - - 5 Some
In vivo CRCM / IPC (UMR-1068) PDX B-ALL - Diagnosis 9 All
In vivo UMR - 1274 PDX B-ALL - - 8 All
In vivo GenCellDis (UMR-944) PDX B-ALL - - - All
In vivo CRCM / IPC (UMR-1068) PDX T-ALL - - 7 All
In vivo UMR - 1274 PDX T-ALL - - 57 Some
In vivo GenCellDis (UMR-944) PDX T-ALL - - - All
In vivo IDMIT (UMR-1184) PDX AML - - - -
In vivo CRCT (UMR-1037) PDX AML - - 55 All
In vivo CRCM / IPC (UMR-1068) PDX AML - Diagnosis 10 All
In vivo CRCM / IPC (UMR-1068) PDX AML - Relapse 14 All
In vivo CRCM / IPC (UMR-1068) PDX AML - - 8 All
In vivo UMR - 1274 PDX AML - - 8 Some
In vivo U1312 BRIC PDX FLT3-ITD AML - - - All
In vivo CRCM / IPC (UMR-1068) PDX APDCL - - 4 None
Exporter les modèles précliniques en fichier XLS